This mini-game can be played in all versions of the game, but it is only important to play this game in the White Water storyline. In all storylines, SPY Fox must buy the Jar of Trinkets and set them on Artimice J. Bigpig's table so he can play against Bigpig.
In the White Water storyline, SPY Fox must play this game in order to win back Captain Drydock's lucky charm. After using the Drydock talk balloon on Bigpig, he reveals he won the lucky charm off the captain after an "intense game of Go Fish". Once SPY Fox wins against Bigpig for the first time, the player must click on the charm so that Bigpig will use the lucky charm as a wager for their next game instead of a trinket. After SPY Fox wins against Bigpig while the charm is the wager, the charm will be added to SPY Fox's inventory.